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CDK5 and MAPT Gene Expression in Alzheimer's Disease Brain Samples
Josianne T Fukasawa1, Roger W de Labio1, Lucas T Rasmussen2
1Marilia School of Medicine (Faculdade de Medicina de Marilia), Marilia Sao Paulo. Brazil.
Current Alzheimer Research
|July 18, 2017
Summary
Alzheimer's disease (AD) is linked to altered cell cycle gene expression. This study found reduced CDK5 gene expression in specific brain regions of AD patients, suggesting a role in neurodegeneration.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid plaques and neurofibrillary tangles.
- Neurons in AD may attempt cell cycle re-entry, leading to cell death and neurodegeneration.
Purpose of the Study:
- To investigate the expression of the MAPT gene and CDK5 (cell cycle regulator) in brain samples from AD patients and controls.
- To determine if gene expression differs across brain regions in AD.
Main Methods:
- Real-time PCR was used to analyze gene expression.
- 150 brain samples from entorhinal cortex, auditory cortex, and hippocampus were analyzed.
- Samples were from 26 AD patients and 24 healthy elderly controls.
Main Results:
- Overall, CDK5 and MAPT gene expression decreased in AD patients.
- Significant reductions in CDK5 mRNA were observed in the hippocampus and entorhinal cortex of AD patients (p=0.0001).
- No significant differences in MAPT gene expression or between brain regions within groups were found.
Conclusions:
- CDK5 gene expression is altered in specific brain regions affected by Alzheimer's disease.
- These findings may enhance understanding of CDK5 and MAPT gene involvement in AD.
- Further research is needed to develop effective therapies for AD.
