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Molecular Targeting of ERKs/RSK2 Signaling in Cancers

Yong-Yeon Cho1

  • 1BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, 43, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Korea.

Current Pharmaceutical Design
|July 18, 2017
PubMed

Insights

p90 ribosomal S6 kinase 2 (RSK2) is crucial in cell growth and cancer. Understanding RSK2 signaling and developing inhibitors offers new therapeutic strategies for human cancers.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • p90 ribosomal S6 kinase 2 (RSK2) is implicated in cell proliferation, transformation, and cancer.
  • RSK2 is an etiological gene associated with Coffin-Lowry Syndrome (CLS).
  • Recent research highlights RSK2's essential role in human cancer development.

Purpose of the Study:

  • To discuss signaling pathways regulating RSK2 activity.
  • To explore the role of RSK2 in human cancer development.
  • To review inhibitors of RSK2 activity and its potential as a drug target.

Main Methods:

  • Signaling analysis
  • Molecular biological approaches

Main Results:

  • RSK2 is a key signaling molecule in cell proliferation and transformation.
  • RSK2 plays an essential role in the development of human cancers.
  • RSK2 activity can be suppressed by specific inhibitors.

Conclusions:

  • RSK2 is a significant target for developing novel cancer therapeutics.
  • Targeting RSK2 signaling pathways may offer new avenues for cancer treatment.
Keywords:
ERK/RSK2Ras signaling pathwaycancercarcinogenesiscell proliferationemerging target

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