Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

1.4K
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
1.4K
Introduction to Electrolytes01:33

Introduction to Electrolytes

17.1K
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
17.1K
Phosphate Buffer01:22

Phosphate Buffer

5.6K
The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
5.6K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

15.3K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.3K
The Phosphorus Cycle01:21

The Phosphorus Cycle

44.5K
Unlike carbon, water, and nitrogen, phosphorus is not present in the atmosphere as a gas. Instead, most phosphorus in the ecosystem exists as compounds, such as phosphate ions (PO43-), found in soil, water, sediment and rocks. Phosphorus is often a limiting nutrient (i.e., in short supply). Consequently, phosphorus is added to most agricultural fertilizers, which can cause environmental problems related to runoff in aquatic ecosystems.
44.5K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

6.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma oxytocin, early predictor of transient postoperative arginine vasopressin deficiency.

The Journal of clinical endocrinology and metabolism·2026
Same author

Renal gluconeogenesis: a key metabolic hub in health and kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Assessing kidney fibrosis via multiparametric MRI in native kidney and allografts.

Clinical kidney journal·2026
Same author

Top ten tips to manage patients after acute kidney injury.

Clinical kidney journal·2026
Same author

Characterization of residual kidney function in chronic hemodialysis patients using plasma metabolomics.

Scientific reports·2026
Same author

Revue medicale suisse·2026

Related Experiment Video

Updated: Feb 26, 2026

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method
08:21

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Published on: May 18, 2018

15.2K

[Phosphate binders : What are the recent evidences ?]

Iméne Achek Bouajila1, Pierre-Yves Martin2, Sophie De Seigneux2

  • 1Service de médecine interne générale, Département de médecine interne générale, HUG, 1211 Genève 14.

Revue Medicale Suisse
|July 18, 2017
PubMed
Summary

Hyperphosphatemia management in chronic kidney disease (CKD) involves dietary changes, phosphate binders, and dialysis. Recent findings suggest limiting calcium-based binders due to increased mortality risks.

More Related Videos

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

9.8K
High-Throughput Measurement and Classification of Organic P in Environmental Samples
08:58

High-Throughput Measurement and Classification of Organic P in Environmental Samples

Published on: June 8, 2011

13.4K

Related Experiment Videos

Last Updated: Feb 26, 2026

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method
08:21

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Published on: May 18, 2018

15.2K
Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

9.8K
High-Throughput Measurement and Classification of Organic P in Environmental Samples
08:58

High-Throughput Measurement and Classification of Organic P in Environmental Samples

Published on: June 8, 2011

13.4K

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Hyperphosphatemia is a significant complication in chronic kidney disease (CKD).
  • It represents a major non-traditional cardiovascular risk factor in CKD patients.
  • Current management strategies include dietary phosphate restriction, phosphate binders, and dialysis.

Purpose of the Study:

  • To review the current management of hyperphosphatemia in CKD.
  • To discuss the risks associated with calcium-based phosphate binders.
  • To explore emerging therapies for hyperphosphatemia.

Main Methods:

  • Literature review of current guidelines and recent evidence.
  • Analysis of comparative studies on phosphate binder efficacy and safety.
  • Overview of novel therapeutic targets for phosphate absorption inhibition.

Main Results:

  • Phosphate binders are categorized into calcium-based and non-calcium-based.
  • Evidence indicates higher mortality with calcium-based binders compared to non-calcic alternatives.
  • New treatments focusing on kidney and intestinal phosphate absorption are in development.

Conclusions:

  • Restricting the dosage of calcium-based phosphate binders is recommended.
  • Non-calcium-based binders may offer a safer alternative.
  • Emerging therapies hold promise for improving patient compliance and managing hyperphosphatemia.