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Delayed transplantation may affect intellectual ability in children

Jiwon M Lee1,2, Yeon Kyung Jung3, Jeong-Hoon Bae3

  • 1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Pediatrics International : Official Journal of the Japan Pediatric Society
|July 18, 2017
PubMed

Insights

Longer illness duration before organ transplantation (Tx) negatively impacts cognitive function in children. Early Tx may improve cognitive outcomes in pediatric patients.

Area of Science:

  • Pediatric medicine
  • Neuroscience
  • Transplantation surgery

Background:

  • Neurocognitive decline is a concern in children with chronic illnesses.
  • Major surgery or trauma may adversely affect cognitive performance in pediatric patients.

Purpose of the Study:

  • To evaluate cognitive function in Korean children post-organ transplantation (Tx).
  • To identify clinical factors associated with cognitive outcomes in pediatric transplant recipients.

Main Methods:

  • Cognitive function assessed using IQ, SQ, and Continuous Performance Test (CPT) in 43 pediatric kidney (KT) or liver transplant (LT) recipients.
  • Intellectual delay classified as intellectual disability (ID) or low intelligence (LI); ADHD diagnosed by psychiatrists.

Main Results:

  • Prevalence of ID was 11.6%, LI was 32.5%, and ADHD was 32.5%.
  • Longer pre-Tx duration of illness significantly correlated with low intelligence (LI) (OR=1.263, P=0.023).
  • Pre-Tx duration was more impactful than age at Tx or total disease duration.

Conclusions:

  • Extended pre-transplant illness duration may impair intellectual ability in pediatric patients.
  • Early organ transplantation could be beneficial for enhancing cognitive function in children.
  • Findings highlight the importance of timely intervention in pediatric chronic illness management.
Abstract

Keywords:
attention-deficit-hyperactivity disordercognitive impairmentintelligencepediatricstransplantation

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