Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Low T4 syndrome in alcoholism: role of the decrease in TBG].

F Grimaldi, S De Marchi, E Cecchin

    Minerva Medica
    |March 17, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).

    ESMO open·2025
    Same author

    Early combination of sotrovimab with nirmatrelvir/ritonavir or remdesivir is associated with low rate of persisting SARS CoV-2 infection in immunocompromised outpatients with mild-to-moderate COVID-19: a prospective single-centre study.

    Annals of medicine·2024
    Same author

    Ten-year experience with pharmacogenetic testing for <i>DPYD</i> in a national cancer center in Italy: Lessons learned on the path to implementation.

    Frontiers in pharmacology·2023
    Same author

    Knowledge, attitudes and adherence towards influenza and other vaccinations among healthcare workers at the University Hospital of Palermo, Italy, during the first COVID-19 pandemic season (2020/2021).

    Annali di igiene : medicina preventiva e di comunita·2023
    Same author

    Implementation of dihydropyrimidine dehydrogenase deficiency testing in Europe.

    ESMO open·2023
    Same author

    Long-term Cryopreserved Autologous Hematopoietic Stem Cells Following Azacytidine to Successfully Treat Severe Invasive Pulmonary Aspergillosis After Therapy-Related Myelodysplastic Syndrome and CD8<sup>+</sup> T-cell Autoimmune Disorders: A Case Report.

    Clinical lymphoma, myeloma & leukemia·2021
    Same journal

    How to become a centenarian in four weeks?. Myths and limits of longevity recipes: a critical review.

    Minerva medica·2026
    Same journal

    Comparative efficacy and safety between intravenous recombinant human prourokinase and alteplase in acute ischemic stroke treatment: a meta-analysis of randomized controlled trials.

    Minerva medica·2026
    Same journal

    Efficacy and safety of oral tapentadol for cancer-related pain: an updated systematic review and meta-analysis.

    Minerva medica·2026
    Same journal

    Use of the neurostimulator in thyroidectomy procedures: comparison between vagal and recurrent laryngeal nerve stimulation.

    Minerva medica·2026
    Same journal

    Iron deficiency and risk of acute kidney injury after TAVI: a machine learning analysis.

    Minerva medica·2026
    Same journal

    Therapeutic adherence and health literacy: a perfect match in dyslipidemic patients.

    Minerva medica·2026
    See all related articles

    Chronic alcohol abuse lowers total thyroxine (T4) by reducing thyroxine-binding globulin (TBG) levels, independent of liver disease. Abstinence rapidly normalizes these thyroid hormone transport proteins.

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Toxicology

    Context:

    • Chronic alcohol consumption is prevalent and associated with various health issues.
    • Thyroid function abnormalities are reported in alcoholics, but data on thyroxine transport are controversial.
    • Liver disease is a common complication of alcoholism, potentially affecting thyroid hormone metabolism.

    Purpose:

    • To investigate thyroxine (T4) transport and metabolism in chronic alcoholics without clinical liver disease.
    • To assess the impact of alcohol abuse on serum T4, free T4 (FT4), and thyroxine-binding globulin (TBG) levels.
    • To determine the effect of alcohol abstinence on these thyroid parameters.

    Summary:

    • In 45 chronic alcoholics without liver disease, serum T4 and TBG were significantly lower than in controls.

    Related Experiment Videos

  • Free T4 (FT4) levels did not differ, indicating that reduced T4 was linked to decreased TBG, not altered free hormone availability.
  • Alcohol intake correlated strongly with TBG levels; abstinence led to rapid normalization of T4 and TBG, suggesting a direct effect of alcohol on TBG synthesis.

    • Impact:

    • Provides evidence that alcohol abuse directly impacts TBG synthesis, leading to reduced total T4.
    • Highlights a "low TBG syndrome" in alcoholics, distinct from liver-induced changes.
    • Suggests that thyroid function monitoring in alcoholics should consider TBG levels and the impact of alcohol intake.