Community effectiveness of pyriproxyfen as a dengue vector control method: A systematic review

Area of Science:

• Medical Entomology
• Public Health
• Vector-Borne Disease Control

Background:

• Dengue prevention relies on vector control, with pyriproxyfen showing promise.
• The autodissemination method using pyriproxyfen can reach difficult breeding sites.
• Pyriproxyfen mimics juvenile hormones, aiding insecticide resistance management in Aedes vectors.

Purpose of the Study:

• To systematically review evidence on pyriproxyfen's community effectiveness (CE) for controlling Aedes populations.
• To analyze pyriproxyfen's impact on reducing human dengue transmission.

Main Methods:

• Conducted a systematic literature search across multiple databases (PubMed, Embase, etc.).
• Screened abstracts and assessed study eligibility, extracting relevant data.
• Classified pyriproxyfen applications into container treatment, fumigation, auto-dissemination, or combination treatments.

Main Results:

• Pyriproxyfen effectively reduced immature Aedes mosquitoes across various application methods.
• Combining pyriproxyfen with other products enhanced efficacy and persistence, potentially slowing resistance.
• Evidence for area-wide ultra-low volume treatments is lacking; community participation effectiveness varied.

Conclusions:

• Pyriproxyfen effectively controls immature and adult dengue mosquitoes.
• Weak evidence exists for pyriproxyfen's ability to reduce human dengue cases.
• Further large-scale studies are needed, and pyriproxyfen resistance requires investigation.