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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Metabolic Effects of Intermittent Fasting
Ruth E Patterson1,2, Dorothy D Sears1,2,3
1Moores Cancer Center, University of California, San Diego, La Jolla, California 92093;
Annual Review of Nutrition
|July 19, 2017
Summary
Intermittent fasting may aid weight loss and improve metabolic health by influencing circadian biology, the gut microbiome, and lifestyle behaviors. These eating patterns offer promising non-pharmacological health benefits.
Area of Science:
- Nutrition Science
- Metabolic Health
- Chronobiology
Background:
- Intermittent fasting (IF) encompasses various eating patterns with potential health benefits.
- Understanding the physiological mechanisms of IF is crucial for its application.
- Current research explores IF's impact on weight management and metabolic parameters.
Purpose of the Study:
- To review intermittent fasting regimens.
- To summarize evidence on IF's health benefits.
- To discuss the physiological mechanisms underlying IF's effects on health.
Main Methods:
- A comprehensive literature search was conducted using MEDLINE via PubMed.
- Keywords included: "intermittent fasting," "fasting," "time-restricted feeding," and "food timing."
- The review synthesized findings from relevant studies.
Main Results:
- Modified fasting regimens show potential for promoting weight loss.
- Evidence suggests IF may improve metabolic health markers.
- Prolonging nightly fasting intervals may lead to sustained health improvements.
Conclusions:
- Intermittent fasting influences metabolic regulation through circadian biology, the gut microbiome, and lifestyle factors.
- IF regimens offer promising non-pharmacological approaches for population health improvement.
- Further research is needed to confirm the efficacy and long-term benefits of IF.
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