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Association study to evaluate TFPI gene in CAD in Han Chinese
Ying Zhao1, Yanbo Yu2, Maowei Shi1
1Department of Geriatrics, Jinan Military General Hospital, Jinan, 250031, China.
Insights
Genetic variations in Tissue Factor Pathway Inhibitor (TFPI) are linked to coronary artery disease (CAD) in Han Chinese populations. These TFPI gene variations may interact with diabetes mellitus, a key risk factor for CAD.
Area of Science:
- Cardiovascular Genetics
- Hemostasis and Thrombosis
- Molecular Medicine
Background:
- Tissue Factor Pathway Inhibitor (TFPI) is a primary regulator of TF-induced coagulation.
- TFPI dysfunction is implicated in major adverse cardiac events.
- Understanding TFPI's role in coronary artery disease (CAD) pathogenesis is crucial.
Purpose of the Study:
- To investigate the association between TFPI gene variations and CAD in the Han Chinese population.
- To identify specific TFPI single-nucleotide polymorphisms (SNPs) linked to CAD risk.
Main Methods:
- Genotyping of four TFPI tagging SNPs (rs7586970, rs6434222, rs10153820, rs8176528) in 1271 CAD patients and 1287 controls.
- Direct sequencing was employed for SNP genotyping.
- Stratified analyses were performed based on clinical risk factors.
Main Results:
- No significant association was found for TFPI SNPs rs10153820 and rs8176528 with CAD.
- TFPI SNPs rs7586970 and rs6434222 showed a significant association with CAD in the study population.
- Genetic variations in TFPI appeared related to diabetes mellitus in CAD patients.
Conclusions:
- Genetic variations in the TFPI gene are associated with coronary artery disease.
- TFPI gene variations may interact with diabetes mellitus, a metabolic risk factor, in CAD development.
- These findings highlight the critical role of TFPI in the pathogenesis of coronary artery disease.
Background:
Tissue factor pathway inhibitor (TFPI) is the main physiological inhibitor of TF-induced blood coagulation process, and may play essential roles in the pathogenesis of major adverse cardiac events. This study was designed to determine whether the variation of TFPI was related with coronary artery disease (CAD) in the Han Chinese populations.
Methods:
A total of 1271 patients with coronary atherosclerosis and 1287 normal individuals from northern China were enrolled in the present study. Four tagging single-nucleotide polymorphisms (SNPs) (rs7586970, rs6434222, rs10153820 and rs8176528) from TFPI were selected and genotyped by direct sequencing. And the genotypes of the above SNPs were determined in all these participants.
Results:
In the populations from Beijing and Harbin, no significant case-control differences in the frequencies of TFPI polymorphism (rs10153820 and rs8176528) were observed between CAD patients and controls. Meanwhile, two SNPs of TFPI (rs7586970 and rs6434222) were found to be associated with CAD in both groups. In stratified analyses based on gender, smoking, hypertension, diabetes mellitus and hyperlipidemia, we further determined that the investigated genetic variations of the TFPI genes seemed to be related with diabetes mellitus in CAD patients.
Conclusions:
Genetic variations of the TFPI genes seem to be related with CAD, which likely cooperate with metabolic risk factor (diabetes mellitus) and play critical roles in the pathogenesis of coronary artery disease.
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