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Updated: Feb 26, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Degradation of cytosolic ribosomes by autophagy-related pathways
Diane C Bassham1, Gustavo C MacIntosh2
1Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Abstract:
Ribosomes are essential molecular machines that require a large cellular investment, yet the mechanisms of their turnover are not well understood in any eukaryotic organism. Recent advances in Arabidopsis suggest that plants utilize selective mechanisms to transport rRNA or ribosomes to the vacuole, where rRNA is degraded and the breakdown products recycled to maintain cellular homeostasis. This review focuses on known mechanisms of rRNA turnover and explores unanswered questions on the specificity and pathways of ribosome turnover and the role of this process in maintenance of cellular homeostasis.
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