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Interleukin-32 in chronic inflammatory conditions is associated with a higher risk of cardiovascular diseases

Michelle S M A Damen1, Calin D Popa2, Mihai G Netea1

  • 1Department of Internal Medicine, Radboud Center for Infectious Diseases (RCI), Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands.

Atherosclerosis
|July 19, 2017
PubMed

Insights

Interleukin-32 (IL-32) may link chronic inflammation to cardiovascular diseases (CVD). This cytokine influences inflammatory pathways and may contribute to atherosclerosis, increasing CVD risk in inflammatory conditions.

Area of Science:

  • Immunology
  • Cardiology
  • Inflammation research

Background:

  • Cardiovascular diseases (CVD) are a leading cause of mortality, particularly in individuals with chronic inflammatory conditions.
  • Inflammatory status significantly contributes to the development and stability of atherosclerotic plaques, underlying CVD pathogenesis.
  • Emerging evidence implicates Interleukin-32 (IL-32) in processes relevant to both inflammation and atherosclerosis.

Purpose of the Study:

  • To review recent advances concerning the role of IL-32 in chronic inflammatory disorders.
  • To explore the potential involvement of IL-32 in the elevated prevalence of CVD observed in patients with inflammatory conditions.

Main Methods:

  • Literature review of recent studies on IL-32.
  • Analysis of IL-32's modulation of key inflammatory pathways (e.g., TNFα, IL-6, IL-1β).
  • Examination of IL-32's suggested effects on endothelial function and high-density lipoprotein (HDL) levels.

Main Results:

  • IL-32 modulates critical inflammatory pathways implicated in inflammatory diseases and atherosclerosis.
  • IL-32 may influence endothelial cell function.
  • Potential impact of IL-32 on serum high-density lipoprotein (HDL) concentrations.

Conclusions:

  • IL-32 is a potential mediator linking chronic inflammatory disorders to increased cardiovascular disease risk.
  • Further research into IL-32's role could offer new therapeutic targets for managing CVD in inflammatory conditions.

Keywords:
AtherosclerosisChronic inflammatory diseasesChronic obstructive pulmonary disease (COPD)InflammationInflammatory bowel disease (IBD)Interleukin- (IL-) 32Rheumatoid arthritis

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