Related Experiment Video
Updated: Feb 26, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Delayed Polyneuropathy Induced by Organophosphate Poisoning
Shunsuke Kobayashi1, Reiko Okubo2, Yoshikazu Ugawa1
1Department of Neurology, Fukushima Medical University, Japan.
Organophosphate poisoning from trichlorfon ingestion can cause delayed, progressive sensory and motor polyneuropathy. Nerve conduction studies are crucial for diagnosing this rare complication.
Area of Science:
- Toxicology
- Neurology
Background:
- Organophosphate pesticides are widely used, and acute poisoning can be life-threatening.
- Delayed neurotoxicity is a rare but serious complication of organophosphate exposure.
Observation:
- An 89-year-old male ingested trichlorfon in a suicide attempt.
- Following initial intensive care, he developed progressive distal weakness and sensory disturbances.
Findings:
- Electrophysiological examinations confirmed a sensory motor axonal polyneuropathy.
- This case highlights delayed polyneuropathy as a rare manifestation of organophosphate poisoning.
Implications:
- Early diagnosis and management of delayed neurotoxicity are essential.
- Nerve conduction studies are vital for identifying this uncommon neurological condition.
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...
Indirect-Acting Cholinergic Agonists: Pharmacokinetics
Reversible agents containing quaternary amines, such as neostigmine and edrophonium, are not easily absorbed orally because they...

