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MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis
Yongpeng Xie1,2, Xin Ma1, Luyao Chen3
1Department of Urology/State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital/PLA Medical School, Beijing, People's Republic of China.
Abstract:
The aim of this study was to systematically review articles that investigated the prognostic significance of different microRNAs in bladder cancer (BC). We systematically searched PubMed, Web of Science, and Embase to identify relevant studies until March 2016. After screening, 26 studies that involved 2753 patients were included. Results suggested that many miRs expression aberration may predict prognosis in patients with BC. There are six miRs (miR-21, miR-143, miR-155, miR-200, miR-214, and miR-222) were reported by at least two studies, and we performed meta-analysis in the corresponding studies. Accordingly, we found that high miR-21 expression was associated with poor overall survival [OS; hazard ratio (HR) = 3.94, 95% CI 2.08-7.44]. High miR-143 expression was associated with poor progression-free survival (PFS; HR = 3.78, 95% CI 1.61-8.89). High miR-155 expression was associated with poor PFS (HR = 8.10, 95% CI 2.92-22.48). High miR-222 expression was associated with poor OS (HR = 3.39, 95% CI 1.10-10.41). Meanwhile, low miR-214 expression was correlated with poor RFS(HR = 0.34, 95% CI 0.22-0.53). Our comprehensive systematic review concluded that microRNAs, particularly miR-21, miR-143, miR-155, miR-214, and miR-222, could serve as meticulous follow-up markers for early detection of progression or recurrence and even useful therapeutic targets for the treatment in patients with BC.
Insights
MicroRNAs can predict bladder cancer prognosis. Specific microRNAs like miR-21 and miR-143 are linked to survival outcomes, suggesting their potential as diagnostic markers and therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Bladder cancer (BC) prognosis is influenced by various factors.
- MicroRNAs (miRs) are emerging as critical regulators in cancer development and progression.
- Identifying reliable prognostic markers in BC is crucial for patient management.
Purpose of the Study:
- To systematically review and analyze studies investigating the prognostic significance of microRNAs in bladder cancer.
- To identify specific microRNAs that can predict survival outcomes in BC patients.
Main Methods:
- Systematic literature search of PubMed, Web of Science, and Embase databases.
- Inclusion of 26 studies involving 2753 patients.
- Meta-analysis performed on six commonly reported microRNAs (miR-21, miR-143, miR-155, miR-200, miR-214, miR-222).
Main Results:
- Aberrant microRNA expression is associated with BC prognosis.
- High miR-21 and miR-222 expression correlated with poor overall survival (OS).
- High miR-143 and miR-155 expression linked to poor progression-free survival (PFS).
- Low miR-214 expression associated with poor recurrence-free survival (RFS).
Conclusions:
- MicroRNAs, especially miR-21, miR-143, miR-155, miR-214, and miR-222, show significant prognostic value in bladder cancer.
- These microRNAs can serve as potential biomarkers for early detection of BC progression or recurrence.
- MicroRNAs may represent novel therapeutic targets for bladder cancer treatment.
