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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Related Experiment Video

Updated: Feb 26, 2026

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

Published on: June 28, 2017

High performance micro-flow cytometer based on optical fibres.

S Etcheverry^1,2, A Faridi³, H Ramachandraiah³

¹Department of Applied Physics, KTH Royal Institute of Technology, Stockholm, Sweden. sec@kth.se.

Scientific Reports

|July 19, 2017

Summary

This summary is machine-generated.

A novel all-silica fibre microflow cytometer offers a portable, low-cost solution for point-of-care diagnosis. This system achieves high throughput and performance comparable to commercial flow cytometers.

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Last Updated: Feb 26, 2026

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

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Published on: June 28, 2017

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Microfluidics

Background:

Flow cytometry is a crucial tool in medical laboratories and research.
Miniaturization and cost reduction are key goals for point-of-care diagnostic applications.
Existing microflow cytometers often lack versatility and speed compared to larger systems.

Purpose of the Study:

To develop a compact, cost-effective, and high-performance microflow cytometer.
To enable point-of-care cell analysis with capabilities rivaling commercial systems.
To overcome limitations of current microfluidic cytometry systems.

Main Methods:

An all-silica fibre microflow cytometer integrating capillary cell transport and optical fibre light delivery.
Elasto-inertial microfluidics for single-stream cell focusing.
Measurement of fluorescence and scattering from particles and cells.

Main Results:

The system demonstrates accurate and sensitive detection of particles and cells.
Achieved high flow rates up to 800 µl/min, with a throughput of 2500 particles/s.
The developed microflow cytometer is robust, portable, and low-cost.

Conclusions:

The presented all-silica fibre microflow cytometer is a viable platform for point-of-care diagnostics.
This technology offers a pathway to democratize advanced cell analysis.
The system's performance and portability pave the way for widespread adoption in clinical settings.