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Physical activity does not alter prolactin levels in post-menopausal women: results from a dose-response randomized
Darren R Brenner1,2,3, Yibing Ruan1, Andria R Morielli4
1Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 - 2nd St. SW, Calgary, AB T2S 3C3 Canada.
Background:
Increased circulating levels of prolactin have been associated with increased risk of both in situ and invasive breast cancer. We investigated whether or not physical activity had a dose-response effect in lowering plasma levels of prolactin in postmenopausal women.
Methods:
Four hundred previously inactive but healthy postmenopausal women aged 50-74 years of age were randomized to 150 or 300 min per week of aerobic physical activity in a year-long intervention. Prolactin was measured from fasting samples with a custom-plex multiplex assay.
Results:
A high compared to moderate volume of physical activity did not reduce plasma prolactin levels in intention-to-treat (Treatment Effect Ratio (TER) 1.00, 95% Confidence Interval (CI) 0.95 - 1.06) or per-protocol analyses (TER 1.02, 95% CI 0.93 - 1.13).
Conclusions:
It is unlikely that changes in prolactin levels mediate the reduced risk of breast cancer development in post-menopausal women associated with increased levels of physical activity.
Trial Registration:
clinicaltrials.gov identifier: NCT01435005.
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