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Area of Science:

  • Oncology
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) risk factors are linked to androgen-deprivation therapy (ADT) in non-African populations.
  • The association between ADT and CVD risk factors in the African population remains understudied.

Purpose of the Study:

  • To investigate the relationship between ADT and cardiovascular disease risk factors in the African population.
  • To determine if ADT influences parameters such as lipid profile, BMI, and waist circumference in African men with prostate cancer.

Main Methods:

  • A cross-sectional study was conducted with 153 prostate cancer patients and 80 controls.
  • Measurements included prostate-specific antigen, waist circumference, BMI, lipid profile, glucose, and insulin levels.
  • Patients were categorized into treatment-naïve and ADT subgroups.

Main Results:

  • Patients on ADT exhibited significantly higher total cholesterol, LDL cholesterol, BMI, and waist circumference compared to treatment-naïve patients.
  • Longer ADT duration (>1 year) correlated with more pronounced increases in BMI, waist circumference, total cholesterol, and LDL cholesterol.
  • No significant differences in glucose or insulin levels were observed between groups.

Conclusions:

  • ADT is associated with elevated cardiovascular disease risk factors, including increased cholesterol, LDL cholesterol, BMI, and waist circumference.
  • Routine screening for these CVD risk factors is recommended for prostate cancer patients receiving ADT.
  • Orchiectomy combined with hormone manipulation showed fewer CVD risk factors than hormone manipulation alone.