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Cardiovascular Disease Risk Factors: How Relevant in African Men With Prostate Cancer Receiving Androgen-Deprivation

Okon Ekwere Essien1, Iya Eze Bassey1, Rebecca Mtaku Gali1

  • 1, , , and , University of Calabar College of Medical Sciences; , University of Calabar Teaching Hospital, Calabar; and , University of Maiduguri College of Medical Sciences, Maiduguri, Nigeria.

Journal of Global Oncology
|July 19, 2017
PubMed

Insights

Androgen-deprivation therapy (ADT) for prostate cancer increases cardiovascular disease risk factors like high cholesterol and BMI in African populations. Regular screening for these risks is crucial for patients undergoing ADT.

Area of Science:

  • Oncology
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) risk factors are linked to androgen-deprivation therapy (ADT) in non-African populations.
  • The association between ADT and CVD risk factors in the African population remains understudied.

Purpose of the Study:

  • To investigate the relationship between ADT and cardiovascular disease risk factors in the African population.
  • To determine if ADT influences parameters such as lipid profile, BMI, and waist circumference in African men with prostate cancer.

Main Methods:

  • A cross-sectional study was conducted with 153 prostate cancer patients and 80 controls.
  • Measurements included prostate-specific antigen, waist circumference, BMI, lipid profile, glucose, and insulin levels.
  • Patients were categorized into treatment-naïve and ADT subgroups.

Main Results:

  • Patients on ADT exhibited significantly higher total cholesterol, LDL cholesterol, BMI, and waist circumference compared to treatment-naïve patients.
  • Longer ADT duration (>1 year) correlated with more pronounced increases in BMI, waist circumference, total cholesterol, and LDL cholesterol.
  • No significant differences in glucose or insulin levels were observed between groups.

Conclusions:

  • ADT is associated with elevated cardiovascular disease risk factors, including increased cholesterol, LDL cholesterol, BMI, and waist circumference.
  • Routine screening for these CVD risk factors is recommended for prostate cancer patients receiving ADT.
  • Orchiectomy combined with hormone manipulation showed fewer CVD risk factors than hormone manipulation alone.
Abstract

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