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Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
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Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry

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Structure-function relationships of protein-lipopeptide complexes and influence on immunogenicity

Acep R Wijayadikusumah1,2, Lucy C Sullivan1, David C Jackson3,4,5

  • 1Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, VIC, 3000, Australia.

Amino Acids
|July 19, 2017
PubMed
Summary

The lipopeptide R4Pam2Cys enhances immune responses to antigens like ovalbumin (OVA), showing comparable antibody production to Freund's adjuvant. Stereoisomer substitution impacts T cell responses but not adjuvant efficacy.

Keywords:
AntibodyCD8+ T cellsCell-mediated immunityLipopeptidesProtein antigensToll-like receptors

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