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Related Experiment Videos

Benzodiazepine sensitivity in normal human subjects.

D W Hommer, V Matsuo, O Wolkowitz

    Archives of General Psychiatry
    |June 1, 1986
    PubMed
    Summary
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    Diazepam (a benzodiazepine) reduced eye movement speed and cortisol levels while increasing sedation and growth hormone. These effects, linked to diazepam concentration, suggest a way to measure benzodiazepine receptor sensitivity.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Clinical Medicine

    Background:

    • Benzodiazepines are widely used drugs with central nervous system effects.
    • Understanding the dose-dependent physiological and hormonal responses to benzodiazepines is crucial for clinical application.
    • Quantifying benzodiazepine effects can aid in assessing receptor sensitivity.

    Purpose of the Study:

    • To investigate the dose-dependent effects of diazepam on saccadic eye velocity, subjective sedation and anxiety, and plasma hormone levels in healthy volunteers.
    • To explore the correlation between diazepam concentration and observed physiological and hormonal changes.
    • To evaluate saccadic eye velocity as a potential biomarker for benzodiazepine receptor activity.

    Main Methods:

    • Ten healthy volunteers received increasing intravenous doses of diazepam or placebo.

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  • Measurements included saccadic eye velocity, self-rated sedation and anxiety, and plasma cortisol and growth hormone concentrations.
  • Plasma diazepam concentrations were correlated with measured outcomes.

    • Main Results:

    • Diazepam caused a dose-dependent decrease in saccadic eye velocity and plasma cortisol.
    • A dose-dependent increase in self-rated sedation and plasma growth hormone was observed.
    • Changes in eye velocity, sedation, and hormone levels correlated with plasma diazepam concentrations.
    • Self-rated anxiety remained unaffected in this cohort.

    Conclusions:

    • Diazepam exerts dose-dependent effects on eye movements, sedation, and hormone levels, consistent with benzodiazepine receptor-mediated actions.
    • Saccadic eye velocity is a quantifiable and sensitive measure of benzodiazepine effects in humans.
    • This finding supports the use of saccadic eye velocity for assessing benzodiazepine receptor sensitivity.