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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Dpep, a Cell-Penetrating Peptide Targeting ATF5, CEBPB and CEBPD, Synergistically Combines with ABT-263 and Decitabine to Inhibit Cancer Cell Growth and Overcome Dpep Resistance.

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Updated: Feb 26, 2026

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
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Targeting ATF5 in Cancer.

James M Angelastro1

  • 1Department of Molecular Biosciences, University of California, Davis School of Veterinary Medicine, Davis, CA 95616, USA.

Trends in Cancer
|July 19, 2017
PubMed
Summary

Activating transcription factor 5 (ATF5) is crucial for cancer cell survival and proliferation. Targeting ATF5 with cell-penetrating peptides offers a promising strategy to induce cancer cell death while protecting healthy cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Activating transcription factor 5 (ATF5) expression is linked to poorer patient survival across various cancers.
  • ATF5 plays a vital role in promoting cancer cell survival and proliferation.
  • Targeting ATF5 presents a potential strategy for selective cancer cell apoptosis induction.

Purpose of the Study:

  • To investigate the therapeutic potential of targeting ATF5 in cancer treatment.
  • To evaluate the efficacy of cell-penetrating peptides delivering dominant-negative ATF5 cargo.

Main Methods:

  • Utilized cell-penetrating peptides conjugated with dominant-negative ATF5 cargo.
  • Assessed the impact of this targeted therapy on cancer cell lines and in preclinical models.
Keywords:
ATF5CP-d/n-ATF5apoptosiscancercell-penetrating peptidedominant negative

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Main Results:

  • Demonstrated selective induction of apoptosis in cancer cells.
  • Showed efficacy across diverse cancer types including brain, breast, melanoma, and prostate cancers.
  • Observed minimal impact on normal cells, indicating targeted action.

Conclusions:

  • Targeting ATF5 with cell-penetrating peptides is a viable strategy for cancer therapy.
  • This approach offers selective cancer cell apoptosis induction, sparing normal tissues.
  • Further development holds promise for treating multiple cancer types.