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Targeting ATF5 in Cancer

James M Angelastro1

  • 1Department of Molecular Biosciences, University of California, Davis School of Veterinary Medicine, Davis, CA 95616, USA.

Trends in Cancer
|July 19, 2017
PubMed

Insights

Activating transcription factor 5 (ATF5) is crucial for cancer cell survival and proliferation. Targeting ATF5 with cell-penetrating peptides offers a promising strategy to induce cancer cell death while protecting healthy cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Activating transcription factor 5 (ATF5) expression is linked to poorer patient survival across various cancers.
  • ATF5 plays a vital role in promoting cancer cell survival and proliferation.
  • Targeting ATF5 presents a potential strategy for selective cancer cell apoptosis induction.

Purpose of the Study:

  • To investigate the therapeutic potential of targeting ATF5 in cancer treatment.
  • To evaluate the efficacy of cell-penetrating peptides delivering dominant-negative ATF5 cargo.

Main Methods:

  • Utilized cell-penetrating peptides conjugated with dominant-negative ATF5 cargo.
  • Assessed the impact of this targeted therapy on cancer cell lines and in preclinical models.

Main Results:

  • Demonstrated selective induction of apoptosis in cancer cells.
  • Showed efficacy across diverse cancer types including brain, breast, melanoma, and prostate cancers.
  • Observed minimal impact on normal cells, indicating targeted action.

Conclusions:

  • Targeting ATF5 with cell-penetrating peptides is a viable strategy for cancer therapy.
  • This approach offers selective cancer cell apoptosis induction, sparing normal tissues.
  • Further development holds promise for treating multiple cancer types.
Keywords:
ATF5CP-d/n-ATF5apoptosiscancercell-penetrating peptidedominant negative

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