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Updated: Jan 23, 2026

An Assay for Quantifying Protein-RNA Binding in Bacteria
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RNA-Binding Proteins in Cancer: Old Players and New Actors

Bruno Pereira1, Marc Billaud2, Raquel Almeida3

  • 1i3S - Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal.

Trends in Cancer
|July 19, 2017
PubMed

Insights

RNA-binding proteins (RBPs) regulate gene expression after transcription. Dysfunctional RBP-RNA interactions are linked to cancer, highlighting their diverse roles in disease progression and potential as therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • RNA-binding proteins (RBPs) are crucial regulators of post-transcriptional gene expression.
  • RBPs possess versatile RNA-binding domains and structural flexibility, enabling control over numerous transcripts.
  • Alterations in RBP-RNA networks are implicated in cancer development, though a comprehensive understanding is lacking.

Purpose of the Study:

  • To review the evidence linking RBPs to various cancer traits.
  • To emphasize the functional diversity of RBPs in the context of cancer.
  • To assess future research directions for RBPs in cancer studies.

Main Methods:

  • Literature review of existing studies on RBPs and cancer.
  • Analysis of evidence for RBP modulation of cancer hallmarks.
  • Synthesis of findings to identify functional diversity and future trends.

Main Results:

  • RBPs influence multiple cancer-associated phenotypes.
  • RBPs exhibit diverse mechanisms of action in cancer.
  • Current understanding of RBP roles in cancer is fragmented.

Conclusions:

  • RBPs are significant contributors to cancer development and progression.
  • Further research is needed to fully elucidate the complex roles of RBPs in cancer.
  • Targeting RBP-RNA interactions presents a promising avenue for cancer therapy.
Keywords:
RNA-binding proteincancerpost-transcriptional regulationribonucleoprotein complex

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