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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
Exercise and the Hallmarks of Cancer
Ana Ruiz-Casado1, Asunción Martín-Ruiz1, Laura M Pérez2
1Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Majadahonda, 28222 Madrid, Spain.
Abstract:
A wealth of evidence supports an association between regular physical activity (PA) and decreased risk for cancer and cancer mortality. This is clearly an important issue given the growing worldwide incidence of both cancer and physical inactivity. Of further importance is unraveling the biological mechanisms that explain the potential preventive effects of PA against the development of cancer, as this might improve our understanding of cancer biology and assist researchers exploring novel treatment strategies. Here we review mechanistic studies that help explain the anticancer effects of exercise based on how exercise impacts hallmark features of cancer. We also discuss the emerging role of myokines, methodological caveats in the field, and potential questions that remain to be addressed in future research.
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