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Atrial cardiopathy: a mechanism of cryptogenic stroke

Shadi Yaghi1, Hooman Kamel2, Mitchell S V Elkind3,4

  • 1a Department of Neurology, Division of Stroke and Cerebrovascular Diseases , The Warren Alpert Medical School of Brown University , Providence , RI , USA.

Expert Review of Cardiovascular Therapy
|July 19, 2017
PubMed

Insights

Atrial cardiopathy, identified by specific biomarkers, is linked to cryptogenic stroke. Further research is needed to clarify its role and optimize stroke prevention strategies.

Area of Science:

  • Cardiology
  • Neurology
  • Biomarkers

Background:

  • Cryptogenic stroke constitutes 30% of ischemic strokes.
  • Atrial cardiopathy, diagnosed via serum, imaging, or ECG biomarkers, is associated with ischemic stroke, especially embolic subtypes.
  • Inflammation and fibrosis are proposed mechanisms of stroke in atrial cardiopathy.

Purpose of the Study:

  • Summarize data on occult atrial fibrillation and stroke.
  • Provide an overview of stroke mechanisms in atrial cardiopathy.
  • Critically review atrial cardiopathy biomarkers and their stroke association.
  • Suggest therapeutic implications and future research directions.

Main Methods:

  • Literature review and data synthesis on atrial cardiopathy and stroke.
  • Analysis of proposed pathophysiological mechanisms (inflammation, fibrosis).
  • Critical evaluation of existing biomarkers for atrial cardiopathy.
  • Discussion of therapeutic strategies and clinical trial needs.

Main Results:

  • Atrial cardiopathy may be a significant mechanism underlying cryptogenic stroke.
  • Biomarkers of atrial cardiopathy show association with stroke risk.
  • Patients with atrial cardiopathy may benefit from targeted clinical trials.

Conclusions:

  • Atrial cardiopathy represents a potential mechanism for cryptogenic stroke.
  • Clinical trials comparing anticoagulation and antiplatelet therapy are warranted in patients with atrial cardiopathy.
  • Further research is essential to identify the most predictive biomarkers for stroke risk and treatment response.
Abstract

Keywords:
Atrial fibrillationatrial cardiopathyatrial diseaseatrial dysfunctionstroke

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