Related Experiment Video
Updated: Feb 26, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells
Amy L Strong1, Robert B Jones1, Julie Glowacki2
1Center for Stem Cell Research & Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Aim:
Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential.
Methods:
The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old).
Results:
BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling.
Conclusion:
The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.
More Related Videos
07:53Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
Published on: December 10, 2010
10:53Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
Published on: November 9, 2020
Related Concept Videos
Mesenchymal Stem Cells
Tissue Renewal without Stem Cells
However, failure of such a system...
Source And Potency Of Stem Cells
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues