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Benchmarking GATE/Geant4 for 16O ion beam therapy.

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Oxygen ion beam therapy shows promise, but Monte Carlo simulations need validation. The Quantum Molecular Dynamics model in Geant4 accurately simulates oxygen ion beam fragmentation for improved treatment planning.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Science

Background:

  • Oxygen ions are a promising alternative to carbon ions in ion beam therapy due to enhanced biological effectiveness.
  • Monte Carlo (MC) transport codes are crucial for researching oxygen ion beam therapy due to limited experimental beam availability.

Purpose of the Study:

  • To validate the GATE/Geant4 simulation toolkit for oxygen ion beam therapy.
  • To benchmark different physics configurations against experimental data.

Main Methods:

  • Simulated depth dose distributions (DDDs) and charge-changing cross sections for oxygen ions.
  • Compared simulation results against literature experimental data.
  • Evaluated five hadron physics lists and two electromagnetic options within GATE/Geant4.

Main Results:

  • Simulated beam ranges showed less than 0.5% deviation, with most points meeting the gamma index criterion (2%/1 mm).
  • Partial charge-changing cross sections exhibited considerable deviations for some physics configurations.
  • The Quantum Molecular Dynamics (QMD) model demonstrated the best agreement with experimental charge-changing cross sections.

Conclusions:

  • GATE/Geant4 can accurately simulate oxygen ion beam ranges for therapy.
  • The QMD model is recommended for Geant4 to accurately simulate oxygen ion beam fragmentation into lighter ions.
  • Accurate simulation is vital for advancing oxygen ion beam therapy research and application.