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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Updated: Feb 26, 2026

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Intestinal microbiome in scleroderma: recent progress.

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Altered gut microbiota, with fewer beneficial bacteria and more harmful ones, is linked to systemic sclerosis (SSc). These microbial changes may impact gastrointestinal issues in SSc patients.

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Area of Science:

  • Microbiome research
  • Immunology
  • Gastroenterology

Background:

  • Gut microbiota plays a crucial role in immune function and homeostasis.
  • Autoimmune diseases are increasingly being investigated for the role of gut microbiota.
  • Systemic sclerosis (SSc) is an autoimmune disease characterized by significant gastrointestinal problems.

Purpose of the Study:

  • To review the current understanding of microbiome research in systemic sclerosis (SSc).
  • To explore the potentially pathologic role of gut microbiota in SSc.
  • To identify potential microbial targets for treating gastrointestinal dysfunction in SSc.

Main Methods:

  • Review of recent scientific literature on gut microbiota and SSc.
  • Analysis of common gut microbiota perturbations in SSc patients compared to healthy controls.
  • Identification of specific bacterial genera associated with SSc and its symptoms.

Main Results:

  • Patients with SSc exhibit distinct gut microbiota profiles compared to healthy individuals.
  • Decreased abundance of beneficial genera (e.g., Faecalibacterium, Clostridium, Bacteroides) is observed in SSc.
  • Increased abundance of pathbiont genera (e.g., Fusobacterium, Prevotella, Erwinia) is noted in SSc patients.
  • Specific bacterial genera may influence the severity of gastrointestinal symptoms in SSc.

Conclusions:

  • Emerging evidence indicates alterations in gut microbiota are associated with SSc.
  • Further research is required to elucidate the mechanisms linking microbial changes to SSc inflammation and fibrosis.
  • Clinical trials investigating dietary interventions or fecal transplantation for SSc are warranted.