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03:02
Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
Published on: November 11, 2025
413
Obesity and pancreatitis.
Biswajit Khatua1, Bara El-Kurdi, Vijay P Singh
1Department of Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
Current Opinion in Gastroenterology
|July 19, 2017
Summary
Obesity increases acute pancreatitis risk and severity. This review covers mechanisms like lipotoxicity and emerging therapies such as fluid management and lipase inhibitors for better outcomes.
Area of Science:
- Gastroenterology
- Metabolic Disorders
- Inflammation
Background:
- The global obesity pandemic is a significant public health concern.
- Obesity is linked to increased incidence and severity of acute pancreatitis.
Purpose of the Study:
- To review the association between obesity and acute pancreatitis.
- To explore underlying mechanisms and potential therapeutic strategies.
Main Methods:
- Literature review of studies investigating obesity and acute pancreatitis.
- Analysis of mechanisms including metabolic and inflammatory pathways.
- Evaluation of emerging treatment options.
Main Results:
- Obesity elevates acute pancreatitis risk via gallstones, diabetes, and medications.
- Mechanisms of severity include cytokines, adipokines, and lipotoxicity.
- Obesity-associated pancreatic steatosis and peripancreatic fat necrosis worsen outcomes.
Conclusions:
- Obesity contributes to acute pancreatitis incidence and severity.
- Lipolytic unsaturated fatty acid release plays a key role in exacerbating pancreatitis.
- Fluid management and lipase inhibition show promise for improving outcomes.
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