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Chronic granulocytic leukemia: long-term remission in a patient with familial sarcoidosis
Insights
This study details a chronic granulocytic leukemia patient with familial sarcoidosis in remission. Persistent Philadelphia chromosome and low leukocyte alkaline phosphatase suggest ongoing CGL markers despite treatment.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Chronic granulocytic leukemia (CGL) is a myeloproliferative neoplasm characterized by the Philadelphia chromosome.
- Sarcoidosis is an inflammatory disease that can affect multiple organs.
- The co-occurrence of CGL and sarcoidosis is rare, presenting unique clinical challenges.
Abstract:
A patient is described who has chronic granulocytic leukemia (CGL) and familial sarcoidosis, and who has been in complete remission for six years after a single course of busulfan therapy. Her bone marrow Philadelphia chromosome persists and the leukocyte alkaline phosphatase activity remains subnormal. Leukocyte alkaline phosphatase levels in nine white patients with sarcoidosis were all found to be low. Bone marrow chromosomes from two patients with active sarcoidosis showed no Philadelphia chromosome, but one of them, and our patient with CGL, exhibited a pericentric inversion of chromosome 9.