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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Transferrin saturation concentrations associated with telomeric ageing: a population-based study.

Chol Shin1, Inkyung Baik2

  • 11Department of Internal Medicine,Korea University Ansan Hospital,Ansan 15355,Republic of Korea.

The British Journal of Nutrition
|July 20, 2017
PubMed
Summary
This summary is machine-generated.

Iron overload and high transferrin saturation (TSAT) are linked to shorter telomere length, a marker of cellular aging. This suggests labile iron

Keywords:
ALT aspartate transaminaseAST alanine transaminaseBP blood pressureLTL leucocyte telomere lengthMET metabolic equivalentROS reactive oxygen speciesTIBC total Fe-binding capacityTSAT transferrin saturationhs-CRP high-sensitivity C-reactive proteinGeneral populationsIron overloadIron statusTelomere lengthTransferrin saturation

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Area of Science:

  • Biochemistry
  • Gerontology
  • Cellular Biology

Background:

  • Leukocyte telomere length (LTL) is a biomarker for cellular replicative aging.
  • Limited data exist on the association between iron (Fe) overload and LTL.
  • Iron status biomarkers include ferritin, transferrin saturation (TSAT), and total iron-binding capacity (TIBC).

Purpose of the Study:

  • To evaluate the associations between Fe-status biomarkers and LTL in older adults.
  • To investigate the role of iron overload and high-normal TSAT in cellular aging.

Main Methods:

  • Cross-sectional study of 1174 men and women aged 50-79 years.
  • Assayed Fe-status biomarkers (ferritin, TSAT, TIBC) and relative LTL from blood samples.
  • Used multiple linear regression analysis adjusted for confounding variables.

Main Results:

  • Positive association found between LTL and TIBC in the highest quartile.
  • Individuals with TSAT >45% or high-normal TSAT (35-45%) had shorter LTL compared to those with low-normal TSAT (<30%).
  • Less-active or obese individuals with high TSAT showed shorter LTL.

Conclusions:

  • Cellular aging is influenced by iron overload and high-normal TSAT concentrations.
  • Labile iron's pro-oxidant activity may contribute to detrimental effects on cellular aging.
  • Findings support the hypothesis on the negative impact of labile iron on cellular health.