Related Experiment Video
Updated: Feb 26, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems
Mario Jug1, Anita Hafner1, Jasmina Lovrić1
1University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, A. Kovačića 1, 10 000 Zagreb, Croatia.
Abstract:
In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory approval process. Mucosal drug delivery systems are aimed to provide both local and systemic drug action via mucosal surfaces of the body and exhibit significant differences in formulation design, as well as in their physicochemical and release characteristics. Therefore it is not possible to devise a single test system which would be suitable for release testing of such complex dosage forms. This article is aimed to provide a comprehensive review of both compendial and noncompendial methods used for in vitro dissolution/release testing of novel mucosal drug delivery systems aimed for ocular, nasal, oromucosal, vaginal and rectal administration.
More Related Videos
Related Concept Videos
In Vitro Drug Dissolution: Alternative Methods
In Vitro Drug Release Testing: Overview, Development and Validation
In Vitro Drug Dissolution: Compendial Testing Models I
In Vitro Drug Dissolution: Compendial Testing Models II
Oral Drug Delivery Systems: Delayed-Release Systems
Factors Affecting Dissolution: Particle Size and Effective Surface Area

