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AHRQ series on complex intervention systematic reviews-paper 3: adapting frameworks to develop protocols.
Mary Butler1, Richard A Epstein2, Annette Totten3
1Minnesota EPC, University of Minnesota School of Public Health, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Developing a systematic review protocol for complex interventions requires adapting analytic frameworks. Modifications to population, intervention, comparators, and outcomes may be necessary, or alternative frameworks may be better suited.
Area of Science:
- Systematic review methodology
- Complex intervention research
Background:
- Systematic review protocols require detailed scope and methodology.
- Traditional analytic frameworks may need modification for complex interventions.
Purpose of the Study:
- To describe adaptations and alternatives to traditional analytic frameworks for systematic reviews.
- To guide the protocol development for systematic reviews of complex interventions.
Main Methods:
- Identification and description of framework elements.
- Examples of adaptations and alternatives to traditional analytic frameworks.
- Outlining approaches to analytic frameworks for complex interventions.
Main Results:
- Framework modifications are often needed for complex interventions.
- Adaptations may involve population, intervention, comparators, and outcomes.
- Alternative frameworks might be more suitable in some cases.
Conclusions:
- Frameworks can be adapted or alternative ones adopted for systematic reviews of complex interventions.
- Considerations include causal/associative linkages and time elements.
- The specifics of framework adaptation depend on the systematic review's details.
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