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Updated: Feb 26, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
Giant schwannomas of the sciatic nerve
Mohammed As-Sultany1, Najla Ben-Ghashir2, Alpesh Mistry3
1Department of Trauma and Orthopaedics, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK.
Abstract:
We report a very rare case of giant schwannomas of the sciatic nerve in a 39-year-old woman who presented with increasing swelling and discomfort in the posterior aspect of her right thigh. We demonstrate that even with such large tumours, surgical excision could be successfully carried out to resolve all symptoms while causing no permanent nerve damage. It remains paramount that large soft tissue tumours get referred to a sarcoma centre and be managed by a specialist multidisciplinary team.
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