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Related Experiment Videos

Apomorphine anorexia: a further pharmacological characterization.

R Muscat, P Willner, A Towell

    European Journal of Pharmacology
    |April 9, 1986
    PubMed
    Summary

    Low doses of apomorphine reduce food intake by slowing eating rate. This effect is mediated by distinct central dopamine receptors, separate from those affecting eating duration.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Low-dose apomorphine reduces food intake by decreasing eating rate and time.
    • Previous research linked the eating time effect to dopamine autoreceptors in the ventral tegmental area.

    Purpose of the Study:

    • To investigate the pharmacological mechanisms underlying apomorphine's effect on eating rate.
    • To differentiate the receptor populations involved in apomorphine's effects on eating rate versus eating time.

    Main Methods:

    • Administered apomorphine and dopamine, assessing effects on food intake, eating time, and eating rate.
    • Utilized peripheral dopamine antagonist (domperidone) and various receptor antagonists (phentolamine, yohimbine, propranolol, scopolamine, naloxone, methergoline).
    • Tested neuroleptics (pimozide, sulpiride) to block apomorphine's effects.

    Main Results:

    • Dopamine reduced food intake primarily via eating time; domperidone blocked dopamine but enhanced apomorphine's effects.
    • Several antagonists (phentolamine, yohimbine, propranolol, scopolamine, naloxone, methergoline) did not reverse apomorphine's effect on eating rate.
    • Neuroleptics pimozide and sulpiride blocked apomorphine's effects on total food intake, eating time, and eating rate.

    Conclusions:

    • Apomorphine's reduction of eating rate is mediated by central dopamine receptors.
    • This receptor population is anatomically distinct from the one responsible for apomorphine's effect on eating time.

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