Related Experiment Video
Updated: Feb 26, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
32.6K
Targeted therapy in severe asthma today: focus on immunoglobulin E
Girolamo Pelaia1, Giorgio Walter Canonica2, Andrea Matucci3
1Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University Magna Graecia of Catanzaro, Catanzaro.
Drug Design, Development and Therapy
|July 20, 2017
Summary
Omalizumab effectively treats severe allergic asthma by targeting Immunoglobulin E (IgE), offering a personalized approach beyond standard treatments for improved patient quality of life.
Area of Science:
- Allergy and Immunology
- Respiratory Medicine
- Pharmacology
Background:
- Asthma is a complex inflammatory condition where a "one size fits all" approach is insufficient.
- Allergic asthma, driven by Immunoglobulin E (IgE), affects a significant portion of adult asthma patients.
- Targeting upstream factors like IgE is crucial for managing allergic asthma effectively.
Purpose of the Study:
- To review the pathogenesis of severe asthma.
- To examine the role of IgE in allergic asthma.
- To evaluate the efficacy and safety of omalizumab as a targeted therapy for severe allergic asthma.
Main Methods:
- Literature review of asthma pathogenesis and IgE's role.
- Analysis of clinical trial data for omalizumab.
- Examination of real-world clinical practice data for omalizumab.
Main Results:
- Omalizumab is the first targeted therapy for severe allergic asthma.
- Clinical data and practice show omalizumab is safe and effective.
- Targeting IgE interrupts the allergic inflammation cascade.
Conclusions:
- Omalizumab is a well-established, safe, and effective targeted therapy for severe persistent IgE-mediated allergic asthma.
- Personalized treatment approaches, like targeting IgE, are vital for optimal asthma management.
- Understanding asthma phenotypes guides effective therapeutic strategies.
Related Concept Videos
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.0K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.0K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.7K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.7K
01:19Antiasthma Drugs: Leukotriene Modifiers
2.0K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
2.0K
01:17Drugs Used in Lower Respiratory Disorders: Overview
1.3K
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.3K
01:20Asthma: Pathogenesis and Management
1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
01:30Asthma-IV: Diagnostic and Management
3.2K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K