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Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

Daniel J Price1, Mthulisi Khuphe1, Robert P W Davies2

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Chemical Communications (Cambridge, England)
|July 20, 2017
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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