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Chemical Sensing on a Single SERS Particle.

Ying Ma1, Kittithat Promthaveepong1, Nan Li2

  • 1Department of Chemical and Biomolecular Engineering, National University of Singapore , 10 Kent Ridge Crescent, Singapore 119260, Singapore.

ACS Sensors
|July 20, 2017
PubMed
Summary

Researchers developed a novel chemical sensing platform using a single cabbage-like gold microparticle (CLMP) as a surface-enhanced Raman scattering (SERS) substrate. This ultrasensitive method effectively profiles sodium dithionite by monitoring a new Raman reporter

Keywords:
SERSazobenzenesensorsingle particlestimuli-responsive Raman reporter

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Area of Science:

  • Chemical sensing
  • Nanomaterials
  • Spectroscopy

Background:

  • Surface-enhanced Raman scattering (SERS) offers high sensitivity for chemical detection.
  • Developing stable and highly enhancing SERS substrates is crucial for practical applications.
  • Sensitive detection of reducing agents like sodium dithionite is important in various analytical fields.

Purpose of the Study:

  • To develop a novel SERS-based chemical sensing platform.
  • To synthesize a new Raman reporter molecule with multiple fingerprints and high reactivity.
  • To demonstrate the ultrasensitive detection and profiling of sodium dithionite using a single SERS particle.

Main Methods:

  • Synthesis of a cabbage-like gold microparticle (CLMP) as a SERS substrate.
  • Synthesis of a new Raman reporter, bis[4,4'-[dithiodiphenyl azo-phenol] (DTDPAP).
  • In situ monitoring of the reaction between DTDPAP and sodium dithionite using SERS on a single CLMP.

Main Results:

  • The CLMP exhibited high SERS enhancement, acting as an ultrasensitive substrate.
  • The synthesized DTDPAP showed multiple fingerprints and high reactivity toward sodium dithionite.
  • The SERS fingerprint changes of DTDPAP correlated with sodium dithionite concentration.

Conclusions:

  • A new, ultrasensitive SERS chemical sensing platform was successfully developed.
  • The platform enables simple and sensitive profiling of sodium dithionite.
  • This approach holds promise for various analytical and sensing applications.