Related Experiment Video

Updated: Feb 26, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

860

Left ventricular hypertrophy in acute stroke patients with known hypertension

Askiel Bruno1, Desiree D Brooks2, Taryn A Abrams2

  • 1a Department of Neurology , Augusta University , Augusta , GA , USA.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|July 20, 2017
PubMed

Insights

Poor adherence to hypertension treatment significantly increases the risk of left ventricular hypertrophy (LVH) in stroke patients. Identifying and addressing the reasons for poor adherence is crucial for managing uncontrolled hypertension and preventing organ damage.

Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Hypertension affects nearly half of US adults, with many cases remaining uncontrolled.
  • Uncontrolled hypertension is a major risk factor for end-organ damage, including left ventricular hypertrophy (LVH).
  • Investigating reasons for uncontrolled hypertension in acute stroke patients is essential for targeted interventions.

Purpose of the Study:

  • To identify factors associated with uncontrolled hypertension, using LVH as a marker.
  • To explore the relationship between demographic, socioeconomic, and adherence factors and LVH in acute stroke patients with a history of hypertension.

Main Methods:

  • A standardized questionnaire collected demographic, socioeconomic, and adherence data from 300 acute stroke patients.
  • Echocardiographic data was used to assess for LVH in 190 patients with a history of hypertension.
  • Statistical analysis, including multiple logit modeling, identified predictors of LVH.

Main Results:

  • Left ventricular hypertrophy (LVH) was present in 46% of the studied patients.
  • Lower household income and self-reported poor adherence to hypertension treatment were linked to increased LVH risk in univariate analysis.
  • Poor adherence to hypertension treatment was the only significant independent predictor of LVH (OR 1.77, p < 0.05) in multivariable analysis.

Conclusions:

  • Poor adherence to hypertension treatment is a significant independent predictor of LVH in acute stroke patients.
  • The underlying reasons for poor adherence remain unclear in a substantial portion of patients.
  • Further research is required to identify barriers and develop effective strategies to improve hypertension treatment adherence.
Abstract

Keywords:
African Americanbody mass indexhypertensionleft ventricular hypertrophystroke

More Related Videos

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

3.4K
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.6K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
565
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
739
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.4K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
945