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Nutrition, inflammation and cancer
Laurence Zitvogel1,2,3,4, Federico Pietrocola1,5,6,7,8,9, Guido Kroemer1,5,6,7,8,9,10,11
1Gustave Roussy Cancer Campus, Villejuif, France.
Nutrition significantly impacts immune cells, influencing cancer development and treatment outcomes. Understanding these dietary-immune-cancer links is crucial for managing malignant diseases.
Area of Science:
- Nutrition science
- Immunology
- Oncology
Background:
- Nutrition profoundly influences leukocyte function, impacting both pro-inflammatory and anti-cancer immune responses.
- Dietary intake affects the incidence, progression, and therapeutic response of malignant diseases in humans and animal models.
Purpose of the Study:
- To elucidate the molecular mechanisms linking nutrition to cancer via immune and inflammatory pathways.
- To explore how alimentary cues modulate metabolic, microbial, and neuroendocrine systems in cancer development and treatment.
Main Methods:
- Review and synthesis of existing literature on nutrition, immunity, inflammation, and cancer.
- Focus on mechanistic aspects of the interrelationships within the nutrition-immunology-inflammation-cancer triangle.
Main Results:
- Nutrition modulates leukocytes, influencing carcinogenic inflammation and anti-cancer immunity.
- Dietary factors impact disease progression and response to cancer therapies.
Conclusions:
- Nutrition plays a critical role in cancer pathogenesis and treatment efficacy.
- Understanding the molecular interplay between diet, immunity, and inflammation is key to managing cancer.
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