Related Experiment Video
Updated: Feb 26, 2026

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
Published on: April 24, 2021
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases
Aubryanna Hettinghouse1, Ronghan Liu1, Chuan-Ju Liu2
1Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA.
Abstract:
The protein disulfide isomerase (PDI) gene family is a protein family classically characterized by endoplasmic reticulum (ER) localization and isomerase and redox activity. ERp57, a prominent multifunctional member of the PDI family, is detected at various levels in multiple cellular localizations outside of the ER. ERp57 has been functionally linked to a host of physiological processes and numerous studies have demonstrated altered expression and aberrant functionality of ERp57 in association with diverse pathological states. Here, we summarize available knowledge of ERp57's functions in subcellular compartments and the roles of dysregulated ERp57 in various diseases toward an emphasis on the potential utility of therapeutic development of ERp57.
More Related Videos
10:24Simultaneous Flow Cytometric Characterization of Multiple Cell Types Retrieved from Mouse Brain/Spinal Cord Through Different Homogenization Methods
Published on: November 19, 2019
07:04Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
Published on: August 15, 2020
Related Concept Videos
Neural Regulation
Mitogens and the Cell Cycle
Protein Folding Quality Check in the RER
Abnormal Proliferation
Export of Misfolded Proteins out of the ER
EPS and iPS Cells in Disease Research