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Updated: Feb 26, 2026

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
Positron Emission Tomography Scanning for Recurrent Bladder Cancer
James M Wilson1, Robert A Huddart1
1The Royal Marsden Hospital, Sutton, Surrey, UK; The Institute of Cancer Research, Sutton, London, UK.
The benefit of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) over CT for detecting distant relapse remains unclear. Reducing bladder activity is crucial for effective FDG-PET/CT imaging of bladder and pelvic lymph node recurrences.
Area of Science:
- Nuclear medicine
- Radiology
- Oncology imaging
Background:
- Computed tomography (CT) is standard for detecting cancer recurrence.
- 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT offers metabolic information but faces challenges with bladder activity.
- The added value of FDG-PET/CT over CT for distant relapse detection is not definitively established.
Purpose of the Study:
- To evaluate the benefit of FDG-PET/CT compared to CT alone in detecting distant cancer relapse.
- To identify methods for reducing bladder activity to improve FDG-PET/CT imaging of pelvic recurrences.
Main Methods:
- Review of existing literature comparing FDG-PET/CT and CT for relapse detection.
- Analysis of techniques aimed at mitigating urinary excretion and bladder uptake of FDG.
Main Results:
- Uncertainty remains regarding the superior efficacy of FDG-PET/CT over CT in identifying distant metastases.
- Strategies to reduce bladder FDG accumulation are essential for optimizing the diagnostic performance of FDG-PET/CT in the pelvic region.
Conclusions:
- Further research is needed to clarify the role of FDG-PET/CT in detecting distant cancer relapse.
- Effective bladder activity reduction techniques are paramount for enhancing the utility of FDG-PET/CT for pelvic lymph node and bladder wall recurrence assessment.
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