Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Accessory Structures of the Eye01:17

Accessory Structures of the Eye

4.1K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future.

Investigative ophthalmology & visual science·2026
Same author

Principles of resident tissue macrophages revealed by the eye.

Advances in immunology·2026
Same author

Resident tissue macrophages maintain intraocular pressure homeostasis.

Immunity·2026
Same author

Intracameral Puncture Lowers Intraocular Pressure and Triggers an Immune Response in the Conventional Outflow Tract.

Investigative ophthalmology & visual science·2025
Same author

Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration.

The Journal of experimental medicine·2025
Same author

Deep Corneal Nerve Plexus Selective Damage in Persistent Neurotrophic Corneal Epithelial Defects Detected by In Vivo Multiphoton Confocal Microscopy.

Investigative ophthalmology & visual science·2025

Related Experiment Video

Updated: Feb 26, 2026

Conjunctival Commensal Isolation and Identification in Mice
07:52

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

5.0K

A Commencement for Eye Commensals.

Nancy J Reyes1, Daniel R Saban2

  • 1Duke University School of Medicine, Department of Ophthalmology, Durham, NC, USA.

Immunity
|July 21, 2017
PubMed
Summary

A newly discovered mouse eye commensal induces gamma-delta T cell immunity, offering protection against opportunistic infections. This finding suggests a functional ocular microbiome plays a role in immune defense.

More Related Videos

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
08:13

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

Published on: November 11, 2025

589
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

13.2K

Related Experiment Videos

Last Updated: Feb 26, 2026

Conjunctival Commensal Isolation and Identification in Mice
07:52

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

5.0K
In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
08:13

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

Published on: November 11, 2025

589
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

13.2K

Area of Science:

  • Immunology
  • Microbiology
  • Ophthalmology

Background:

  • The ocular surface microbiome's existence and role in immunity are debated due to low bacterial loads.
  • Opportunistic infections pose a risk to eye health.

Purpose of the Study:

  • To investigate the presence and function of a commensal microorganism on the mouse ocular surface.
  • To determine the role of this commensal in immune defense against infection.

Main Methods:

  • Culturing and identification of commensal bacteria from mouse eyes.
  • Immunological assays to assess T cell responses.
  • Challenge studies with opportunistic pathogens.

Main Results:

  • Identification of a novel commensal bacterium on the mouse ocular surface.
  • This commensal induces a gamma-delta T cell response.
  • Mice harboring this commensal show enhanced protection against opportunistic ocular infections.

Conclusions:

  • A functional ocular microbiome exists, comprising naturally occurring commensals.
  • Commensal microorganisms can prime adaptive immune responses, such as gamma-delta T cells.
  • The ocular microbiome contributes to host defense against opportunistic pathogens.