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Leukoencephalopathy with calcifications and cysts: A case report.
Yubao Ma1, Xingwen Zhang, Chen Cheng
1Department of Neurology, Chinese PLA General Hospital, Beijing Department of Neurology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Medicine
|July 21, 2017
Summary
Leukoencephalopathy with calcifications and cysts (LCC) is a rare neurological disorder. This study highlights variable clinical presentations and the need for further research into its causes.
Area of Science:
- Neurology
- Radiology
- Pathology
Background:
- Leukoencephalopathy with calcifications and cysts (LCC) is a rare neurological disorder.
- Characterized by edematous leukoencephalopathy, cerebral calcifications, and parenchymal cysts.
- Its rarity necessitates further elucidation of clinical, radiological, and histopathological features.
Observation:
- Two cases of LCC are presented: a 35-year-old asymptomatic female with an incidentally detected intracranial cyst and a 20-year-old female with headache, intracranial calcifications, and a cyst.
- Radiological findings included a giant intracranial cyst and multiple asymmetric calcifications in the basal ganglia and white matter.
Findings:
- Both patients were diagnosed with LCC.
- Surgical resection of the cyst in the first patient and stereotactic biopsy in the second patient resulted in good postoperative outcomes.
Implications:
- LCC can occur at any age, with younger individuals potentially experiencing more severe symptoms.
- Clinical manifestations of LCC are variable and can be aggressive.
- Further research is required to understand the underlying pathogenic basis of LCC.
