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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Spongy Bone01:09

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Bone turnover after bariatric surgery.

Thalita Lima Melo1, Leila Froeder1, Leandro da Cunha Baia1

  • 1Disciplina de Nefrologia, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.

Archives of Endocrinology and Metabolism
|July 21, 2017
PubMed
Summary

Bariatric surgery patients show increased bone turnover markers, indicating persistent bone formation and resorption long after the procedure. This suggests ongoing changes in bone metabolism for over seven years post-surgery.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Bariatric Surgery Outcomes

Background:

  • Bariatric surgery significantly alters nutrient absorption and hormonal profiles.
  • Understanding long-term effects on bone and mineral metabolism is crucial for patient management.

Purpose of the Study:

  • To evaluate bone and mineral metabolism parameters in patients following bariatric surgery.
  • To compare these parameters with a control group of obese individuals.

Main Methods:

  • Cross-sectional study of 61 bariatric surgery patients (≥6 months post-op) and 30 obese controls.
  • Assessed dietary intake, serum levels of 25(OH)D, parathyroid hormone (PTH), bone alkaline phosphatase (BAP), leptin, FGF-23, and urinary deoxypyridinoline (DPYD).

Main Results:

  • Bariatric surgery patients had lower BMI and intake of energy, carbohydrates, protein, and sodium chloride compared to controls.
  • Serum BAP was significantly higher in bariatric surgery patients, correlating positively with time post-surgery.
  • Leptin levels were lower, and urinary DPYD was higher in the bariatric surgery group.

Conclusions:

  • Bariatric surgery is associated with increased bone formation and resorption markers.
  • Elevated bone turnover persists for over 7 years post-bariatric surgery, indicating long-term metabolic changes.