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Gamma Knife Stereotactic Radiosurgery for Grade 2 Meningiomas
Tamer Refaat1,2,3, Michelle Gentile1, Sean Sachdev1
1Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States.
Journal of Neurological Surgery. Part B, Skull Base
|July 21, 2017
Summary
Gamma Knife radiosurgery (GKRS) offers durable tumor control for grade 2 meningiomas, with minimal toxicity. This study shows GKRS is a safe and effective treatment option for these challenging brain tumors.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Grade 2 meningiomas are challenging tumors requiring effective treatment.
- Long-term outcomes for Gamma Knife radiosurgery (GKRS) in these tumors are not well-established.
Purpose of the Study:
- To report long-term clinical outcomes of GKRS for intracranial grade 2 meningiomas.
- To evaluate the safety and efficacy of GKRS in this patient population.
Main Methods:
- Retrospective review of 97 grade 2 meningiomas in 75 patients treated with GKRS between 1998 and 2014.
- Analysis of local control, overall survival, and treatment-related toxicity.
Main Results:
- Mean follow-up was 41 months, with a 29.79% local recurrence rate.
- 3- and 5-year local control rates were 68.9% and 55.7%, respectively.
- No radiation necrosis or secondary malignancies were observed, indicating minimal toxicity.
Conclusions:
- GKRS is a safe and effective treatment for grade 2 meningiomas, providing durable tumor control.
- Adjuvant GKRS can be considered a reasonable treatment option for patients with grade 2 meningiomas.
