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The Emerging Role of Histone Demethylases in Renal Cell Carcinoma

Xiaoqiang Guo1,2,3, Qiaoxia Zhang1

  • 1State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.

Journal of Kidney Cancer and VHL
|July 21, 2017
PubMed

Insights

Histone demethylases (KDMs) are implicated in kidney cancer (RCC) development. Further research into KDM inhibitors is needed for potential clinical applications in treating this common cancer.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Renal cell carcinoma (RCC) is a prevalent kidney cancer with over 100,000 global deaths annually.
  • The molecular underpinnings of RCC remain incompletely understood, with epigenetics playing a key role.
  • Histone modifications, regulated by histone demethylases (KDMs), are critical in cancer pathogenesis.

Purpose of the Study:

  • To review the current understanding of histone demethylases' roles in renal cell carcinoma.
  • To explore the involvement of specific KDMs (KDM3A, KDM5C, KDM6A, KDM6B) in RCC pathogenesis.
  • To discuss the potential of KDM inhibitors in RCC treatment.

Main Methods:

  • Literature review of existing studies on histone demethylases and renal cell carcinoma.
  • Analysis of evidence linking KDMs to cancer development and progression pathways.
  • Summary of preclinical findings on small-molecule KDM inhibitors.

Main Results:

  • Emerging evidence suggests specific KDMs (KDM3A, KDM5C, KDM6A, KDM6B) are involved in RCC.
  • KDMs may drive RCC development and progression through hypoxia-mediated angiogenesis.
  • Small-molecule KDM inhibitors are under preclinical investigation.

Conclusions:

  • Histone demethylases represent a significant area of interest in renal cell carcinoma research.
  • The precise clinical utility of KDM inhibitors for RCC requires further investigation.
  • Understanding KDM functions is crucial for developing novel therapeutic strategies against kidney cancer.
Keywords:
KDM3AKDM5CKDM6AKDM6Bhistone demethylasesrenal cell carcinoma

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