Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scrapie: how much do we really understand?

R H Kimberlin

    Neuropathology and Applied Neurobiology
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Scrapie strains suggest the infectious agent has a genome, with host genes like Sinc controlling replication and disease progression. The study explores how the agent spreads and forms lesions, focusing on Scrapie Associated Fibrils (SAF) and their protein component.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Creutzfeldt-Jakob disease and the risk from blood or blood products.

    Vox sanguinis·1998
    Same author

    Creutzfeldt-Jakob disease.

    Lancet (London, England)·1996
    Same author

    Bovine spongiform encephalopathy. Epidemiology, low dose exposure and risks.

    Annals of the New York Academy of Sciences·1994
    Same author

    Bovine spongiform encephalopathy: an appraisal of the current epidemic in the United Kingdom.

    Intervirology·1993
    Same author

    Bovine spongiform encephalopathy.

    Revue scientifique et technique (International Office of Epizootics)·1992
    Same author

    Scrapie-infected spleens: analysis of infectivity, scrapie-associated fibrils, and protease-resistant proteins.

    The Journal of infectious diseases·1991
    Same journal

    Diagnostic Alteration Is Not Therapeutic Dependency: Lessons From Failed RET Inhibition in a PLAG-Altered CNS Embryonal Tumour.

    Neuropathology and applied neurobiology·2026
    Same journal

    Respone to Škudar.

    Neuropathology and applied neurobiology·2026
    Same journal

    Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis.

    Neuropathology and applied neurobiology·2026
    Same journal

    Neuropathological and Molecular Features Associated With a Heterozygous DNAJC7 Mutation in Amyotrophic Lateral Sclerosis.

    Neuropathology and applied neurobiology·2026
    Same journal

    Central Nervous System Embryonal Tumour With PLAGL Amplification Lacking Typical Embryonal Morphology: Diagnostic Pitfall in a Paediatric Case.

    Neuropathology and applied neurobiology·2026
    Same journal

    Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies.

    Neuropathology and applied neurobiology·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Infectious Diseases

    Background:

    • Biological studies provide evidence for distinct scrapie strains, some mutating, suggesting the infectious agent possesses a genome.
    • Scrapie incubation periods are influenced by agent strain and host genetic control, exemplified by the Sinc gene in mice affecting central nervous system (CNS) replication rates.

    Purpose of the Study:

    • To investigate the role of host genetics in scrapie pathogenesis and agent replication.
    • To understand the spread of scrapie infection within the CNS and its relationship with lesion development.
    • To characterize Scrapie Associated Fibrils (SAF) and their relationship with the scrapie agent and disease pathology.

    Main Methods:

    • Analysis of scrapie strains and their mutation patterns.

    Related Experiment Videos

  • Investigating host genetic control (Sinc gene) on agent replication in mice.
  • Tracing the spread of infection from peripheral sites to the CNS, including neural pathways.
  • Biochemical characterization of Scrapie Associated Fibrils (SAF) and associated glycoproteins (PrP 27-30).

    • Main Results:

    • Evidence suggests the scrapie agent has a genome, with strains influencing incubation periods.
    • Host genes, such as Sinc in mice, significantly control agent replication rates in the CNS.
    • Infection spreads within the CNS, potentially via autonomic nerves and neurons, correlating with vacuolation and amyloid deposition.
    • Scrapie Associated Fibrils (SAF), composed of a glycoprotein (PrP 27-30), are found in infected brains, with the normal protein potentially modified and accumulating.

    Conclusions:

    • The findings support the hypothesis of an infectious scrapie agent with a genome, influenced by strain variation and host genetics.
    • Understanding agent replication, spread, and targeting within the CNS is crucial for comprehending lesion development patterns.
    • While SAF and PrP 27-30 are strongly associated with scrapie, their exact biochemical nature and role as the infectious agent remain under investigation.