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The effect of chlorpromazine on intracellular Ca2+ concentration in macrophages
Z I Krutetskaya1, L S Milenina2, A A Naumova2
1St. Petersburg State University, St. Petersburg, 199034, Russia. z.krutetskaya@spbu.ru.
Doklady. Biochemistry and Biophysics
|July 21, 2017
Abstract:
Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca2+ concentration increase in macrophages due to Ca2+ mobilization from intracellular Ca2+ stores and subsequent Ca2+ entry from the external medium. Chlorpromazine-induced Ca2+ entry is inhibited by La3+ and 2-aminoethoxydiphenyl borate and is associated with Ca2+ store depletion.

