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[What has the GLAGOV clinical study shown?]

Ján Murín

    Vnitrni Lekarstvi
    |July 21, 2017
    PubMed

    Insights

    Evolocumab, a PCSK9 inhibitor, significantly reduces LDL-cholesterol levels when used with statins. This combined therapy promotes regression of coronary atherosclerosis in patients with ischemic heart disease.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Cardiovascular atherosclerotic disease necessitates lowering LDL-cholesterol (LDL-C).
    • PCSK9 inhibitors, combined with statins, effectively reduce LDL-C levels.

    Purpose of the Study:

    • To evaluate the impact of evolocumab (PCSK9 inhibitor) plus statin therapy on coronary atherosclerosis.
    • To compare this combined therapy against statin-only treatment in patients with ischemic heart disease.

    Main Methods:

    • The GLAGOV study was a multicentric, double-blinded, placebo-controlled trial.
    • 968 patients with ischemic heart disease were treated for 76 weeks with either evolocumab plus statin or statin alone.
    • Changes in serum LDL-C levels and percent atheroma volume in coronary arteries were measured.

    Main Results:

    • Combined therapy significantly lowered LDL-C from 2.39 to 0.95 mmol/l.
    • Percent atheroma volume reduced by 0.95% with combined therapy, versus a 0.05% increase with statin-only therapy.
    • The treatment regimen was found to be safe.

    Conclusions:

    • Evolocumab, in addition to statins, favorably influences coronary atherosclerosis by further reducing LDL-C levels.
    • This supports the use of PCSK9 inhibitors for managing coronary atherosclerosis progression.

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