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Updated: Feb 26, 2026
07:11
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
6.9K
Summary
Evolocumab, a PCSK9 inhibitor, significantly reduces LDL-cholesterol levels when used with statins. This combined therapy promotes regression of coronary atherosclerosis in patients with ischemic heart disease.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Cardiovascular atherosclerotic disease necessitates lowering LDL-cholesterol (LDL-C).
- PCSK9 inhibitors, combined with statins, effectively reduce LDL-C levels.
Purpose of the Study:
- To evaluate the impact of evolocumab (PCSK9 inhibitor) plus statin therapy on coronary atherosclerosis.
- To compare this combined therapy against statin-only treatment in patients with ischemic heart disease.
Main Methods:
- The GLAGOV study was a multicentric, double-blinded, placebo-controlled trial.
- 968 patients with ischemic heart disease were treated for 76 weeks with either evolocumab plus statin or statin alone.
- Changes in serum LDL-C levels and percent atheroma volume in coronary arteries were measured.
Main Results:
- Combined therapy significantly lowered LDL-C from 2.39 to 0.95 mmol/l.
- Percent atheroma volume reduced by 0.95% with combined therapy, versus a 0.05% increase with statin-only therapy.
- The treatment regimen was found to be safe.
Conclusions:
- Evolocumab, in addition to statins, favorably influences coronary atherosclerosis by further reducing LDL-C levels.
- This supports the use of PCSK9 inhibitors for managing coronary atherosclerosis progression.
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