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Updated: Feb 26, 2026
Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
Mechanically strong and pH-responsive carboxymethyl chitosan/graphene oxide/polyacrylamide nanocomposite hydrogels
Yang Chen1,2, Hongqiu Wang1, Junrong Yu1
1a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering , Donghua University , Shanghai , China.
Abstract:
The biocompatible, quickly recoverable, mechanically strong and tough polymer hydrogels have great potential for biomedical applications. A novel carboxymethyl chitosan (CMCTs)/graphene oxide (GO)/polyacrylamide (PAM) nanocomposite (NC) hydrogel with excellent mechanical performance was synthesized through a facile, one-pot free radical polymerization, using GO nanosheets as the crosslink centers instead of toxic organic molecules. The content of GO nanosheets and CMCTs has great influence on the mechanical properties of CMCTs/GO/PAM NC hydrogels. When the amount of GO nanosheets is 0.118 wt % and CMCTs is 1.5 wt % (to the total weight of CMCTs and acrylamide), CMCTs/GO/PAM hydrogel displays a compressive stress as high as 5.8 MPa at the breaking deformation of 87.5% and a tensile strength of 223.6 kPa at the failure strain of 631%. Besides, with nearly complete recovery in 1 min at the room temperature after unloading, the CMCTs/GO/PAM hydrogels exhibit excellent fast recoverability. Additionally, the CMCTs/GO/PAM hydrogels also have an obvious pH-responsive property.
