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Maguari Virus Associated with Human Disease.
Emerging Infectious Diseases
|July 21, 2017
Summary
Maguari virus (MAGV), though not previously linked to human illness, was found in a febrile patient. Genetic analysis confirmed MAGV can cause human disease, challenging prior assumptions.
Area of Science:
- Arbovirology
- Viral genomics
- Public health virology
Background:
- Maguari virus (MAGV) is closely related to Cache Valley virus (CVV), a known human pathogen.
- Previous understanding suggested MAGV did not cause symptomatic human infections.
- The genetic relationship between MAGV and CVV necessitates further investigation into MAGV's pathogenic potential.
Purpose of the Study:
- To sequence and classify a Maguari virus-like isolate (OBS6657) from a febrile patient in Peru.
- To perform comprehensive genomic analysis of MAGV, MAGV-like, and related viruses (CVV, Tlacotalpan, Playas, Fort Sherman).
- To clarify the taxonomic status of MAGV-like isolates and determine if MAGV can cause human disease.
Main Methods:
- Whole-genome sequencing of the OBS6657 isolate and related viral strains.
- Phylogenetic analysis to determine evolutionary relationships between viral isolates.
- Comparative genomic analysis to assess genetic similarity and divergence.
Main Results:
- The OBS6657 isolate was confirmed as MAGV-like, closely resembling the MAGV prototype.
- Two MAGV-like isolates were genetically distinct, suggesting they may represent a new virus species.
- One isolate initially thought to be MAGV-like was reclassified as a Cache Valley virus strain.
- Genomic data provided evidence that MAGV can indeed cause human illness.
Conclusions:
- Maguari virus (MAGV) is capable of causing symptomatic human disease.
- The classification of some MAGV-like viruses requires revision, with potential for new species identification.
- This study highlights the importance of genomic surveillance for understanding arbovirus pathogenicity and evolution.
Keywords:
ArgentinaBrazilCache Valley virusCentral AmericaColombiaEcuadorFort Sherman virusFrench GuianaMaguari virusMexicoPanamaParaguayPeruPlayas virusSouth AmericaTlacotalpan virusUnited Statesarbovirusesbunyavirusdiseasehuman infectionmosquitoesorthobunyavirusphylogenyvector-borne infectionsviruses
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