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Cyclodextrin-based biological stimuli-responsive carriers for smart and precision medicine
Rongqiang Liao1, Pin Lv, Qian Wang
1Department of pharmacy, Chongqing Emergency Medical Center, Chongqing, 400014, P.R. China. liaorongqiang@126.com.
Biomaterials Science
|July 21, 2017
Summary
Smart drug carriers utilizing host-guest interactions with cyclodextrins offer precise, stimuli-responsive drug release. This review explores their design, mechanisms, and applications in precision medicine.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmacology
Background:
- Advancements in nanotechnology and precision medicine are driving innovation in smart drug delivery systems.
- Smart drug carriers enable controlled drug release in response to specific in vivo microenvironments (pH, redox, enzymes).
- Host-guest interactions involving cyclodextrins are a key strategy for fabricating these advanced carriers.
Purpose of the Study:
- To review the features, mechanisms, and applications of biological stimuli-responsive drug carriers based on cyclodextrins.
- To highlight the role of host-guest interactions in assembling molecular-level drug delivery systems.
- To provide insights into the future potential of cyclodextrin-based smart drug carriers.
Main Methods:
- Literature review of recent advancements in stimuli-responsive drug delivery.
- Analysis of host-guest complexation principles for carrier fabrication.
- Discussion of biological stimuli (pH, redox, enzyme) triggering drug release.
- Exploration of supramolecular assembly of drug carriers.
Main Results:
- Cyclodextrin-based host-guest interactions facilitate the creation of sophisticated smart drug carriers.
- These carriers demonstrate controlled drug release in response to specific biological cues.
- The integration of various biological molecules and building blocks is achieved through supramolecular assembly.
- Diverse applications in targeted therapy and precision medicine are emerging.
Conclusions:
- Cyclodextrin-based smart drug carriers represent a significant advancement in drug delivery technology.
- Host-guest chemistry provides a versatile platform for designing stimuli-responsive systems.
- Further research holds promise for expanding the therapeutic applications of these intelligent drug delivery systems.
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