Related Experiment Video
Updated: Feb 26, 2026

08:18
Automated Microbial Cultivation and Adaptive Evolution using Microbial Microdroplet Culture System MMC
Published on: February 18, 2022
4.6K
Adapting VMAT plans optimized for an HD120 MLC for delivery with a Millennium MLC
Samuel B French1,2, Stephen Bhagroo2, Daryl P Nazareth1,2
1Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Journal of Applied Clinical Medical Physics
|July 21, 2017
Summary
This study presents an efficient method to adapt Volumetric Modulated Arc Therapy (VMAT) plans from high-definition to standard-definition multi-leaf collimators (MLCs). This ensures consistent patient treatment delivery despite linac availability challenges.
Area of Science:
- Medical Physics
- Radiation Oncology
- Radiotherapy Technology
Background:
- Linac downtime disrupts patient treatment schedules, necessitating plan transfers between machines.
- Transferring Volumetric Modulated Arc Therapy (VMAT) plans from standard-definition to high-definition multi-leaf collimators (MLCs) is routine.
- Adapting VMAT plans from high-definition MLCs to standard-definition MLCs poses a significant challenge due to differing aperture capabilities.
Purpose of the Study:
- To develop and validate an efficient method for adapting VMAT plans designed for high-definition MLCs for delivery on standard-definition MLCs.
- To assess the dosimetric accuracy and feasibility of using adapted VMAT plans for various cancer sites.
Main Methods:
- Developed a novel computational method to modify VMAT plan aperture shapes from high-definition to standard-definition MLC geometry.
- Applied the adaptation method to VMAT plans for head-and-neck, brain, lung, and prostate cancer treatments.
- Verified the dosimetric accuracy of the adapted plans through phantom measurements and delivery checks.
Main Results:
- The developed method successfully adapted VMAT plans for delivery on standard-definition MLCs.
- Dosimetric analysis confirmed the clinical viability of the adapted plans across diverse treatment sites.
- Phantom measurements validated the accurate delivery of adapted VMAT plans.
Conclusions:
- The efficient adaptation method overcomes the challenge of transferring VMAT plans between different MLC definitions.
- This approach facilitates seamless treatment delivery continuity, even with linac downtime or differing equipment.
- The validated method supports clinical workflows requiring VMAT plan adaptation for standard-definition MLCs.

